Press Release

2023

• 真菌の二次代謝物に新たな殺虫作用 環境に優しい昆虫制御>型農薬に役立つ期待

  2023-09-28

  Kato N, Ebihara K, Nogawa T, Futamura Y, Inaba K, Okano A, Aono H, Fujikawa Y, Inoue H, Matsuda K, Osada H, Niwa R, Takahashi S.: cis-Decalin-containing tetramic acids as inhibitors of insect steroidogenic glutathione S-transferase Noppera-bo.
  PLoS One, 18(8): e0290851 (2023) [ doi: 10.1371/journal.pone.0290851 ]

• 脂肪酸合成を阻害する新たな抗真菌化合物の発見−世界的>脅威である真菌感染症の新しい治療薬として期待−

  2023-07-11

  Iyer KR, Li SC, Revie NM, Lou JW, Duncan D, Fallah S, Sanchez H, Skulska I, Ušaj MM, Safizadeh H, Larsen B, Wong C, Aman A, Kiyota T, Yoshimura M, Kimura H, Hirano H, Yoshida M, Osada H, Gingras AC, Andes DR, Shapiro RS, Robbins N, Mazhab-Jafari MT, Whitesell L, Yashiroda Y, Boone C, Cowen LE.: Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity.
  Cell Chem Biol, 30(7): 795-810.e8 (2023) [ doi: 10.1016/j.chembiol.2023.06.005. ]

2022

• 農薬耐性イネいもち病菌の防除化合物 －理研独自の化合物アレイ技術で探索－

  2022-03-11

  Motoyama T, Kondoh Y, Shimizu T, Hayashi T, Honda K, Uchida M, Osada H.: Identification of Scytalone Dehydratase Inhibitors Effective against Melanin Biosynthesis Dehydratase Inhibitor-Resistant Pyricularia oryzae.
  J Agric Food Chem, 70(10): 3109-3116 (2022) [ doi: 10.1021/acs.jafc.1c04984 ]

• カビから見つけた抗マラリア化合物 －新たな制御薬剤の開発に期待－

  2022-03-04

  A Abdelhakim I, Bin Mahmud F, Motoyama T, Futamura Y, Takahashi S, Osada H.: Dihydrolucilactaene, a Potent Antimalarial Compound from Fusarium sp. RK97-94.
  J Nat Prod, 85(1): 63-69 (2022) [ doi: 10.1021/acs.jnatprod.1c00677 ]

• がん細胞のフェロトーシスを増強する化合物を発見 －フェロトーシス抑制タンパク質FSP1に対する新しい阻害剤－

  2022-02-09

  Yoshioka H, Kawamura T, Muroi M, Kondoh Y, Honda K, Kawatani M, Aono H, Waldmann H, Watanabe N, Osada H.: Identification of a Small Molecule That Enhances Ferroptosis via Inhibition of Ferroptosis Suppressor Protein 1 (FSP1).
  ACS Chem Biol, 17(2): 483-491 (2022) [ doi: 10.1021/acschembio.2c00028 ]

• B型肝炎ウイルス感染を抑制する抗体を開発 －ウイルス侵入受容体をターゲットにした新しい抗体医薬に貢献－

  2022-01-14

  Takemori T, Sugimoto-Ishige A, Nishitsuji H, Futamura Y, Harada M, Kimura-Someya T, Matsumoto T, Honma T, Tanaka M, Yaguchi M, Isono K, Koseki H, Osada H, Miki D, Saito T, Tanaka T, Fukami T, Goto T, Shirouzu M, Shimotohno K, Chayama K.: Establishment of a Monoclonal Antibody against Human NTCP That Blocks Hepatitis B Virus Infection.
  J Virol, 96(5): e0168621 (2022) [ doi: 10.1128/JVI.01686-21 ]

-2021

　Press releases through 2021 are available on the Chemical Biology Research Group's website.

　　　　Chemical Biology Research Groups Press release

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