Original Articles

2025

1. Futamura Y, Yamamoto K, Uson-Lopez R, Aono H, Shimizu T, Hori Y, Kino K, Osada H.: Inhibitory effect of copper chelators on the budding in Candida albicans.
   Antimicrob Agents Chemother, [Epub ahead of print] (2025) [ doi: 10.1128/aac.00033-25 ]
2. Fitriastuti D, Miura K, Okada S, Hirano H, Osada H, Nakamura H.: Discovery of niclosamide as a p300/transcription factor protein-protein interaction inhibitor.
   Bioorg Med Chem, 121:118114 (2025) [ doi: 10.1016/j.bmc.2025.118114 ]
3. Watanabe N, Sanada E, Okano A, Nogawa T, Lai NS, Mazaki Y, Muroi M, Yashiroda Y, Yoshida M, Osada H.: Violaceoid F induces nuclear translocation of FOXO3a by inhibiting CRM1 via a novel mechanism and suppresses HeLa cell growth.
   FEBS Lett, 599(5): 755-765 (2025) [ doi: 10.1002/1873-3468.15085 ]
4. Wang Y, Li L, Chen D, Shan J, Yi M, Osada H, Yoshida M, Xiang L, Qi J.: GENI as an AMPK activator binds α and γ subunits and improves the memory dysfunction of Alzheimer's disease mouse models via autophagy and neuroprotection.
   Antioxidants, 14(1): (2025) [ doi: 10.3390/antiox14010057 ]
5. Miyaji T, Yamagami A, Nakamura Y, Nishida K, Tachibana R, Surina S, Fujioka S, Garcia-Hourquet M, Mora-García S, Nosaki S, Miyakawa T, Tanokura M, Matsui M, Osada H, Shinozaki K, Asami T, Nakano T.: BIL7 enhances plant growth by regulating the transcription factor BIL1/BZR1 during brassinosteroid signaling.
   Plant J, 121(2): e17212 (2025) [ doi: 10.1111/tpj.17212 ]

2024

1. Toda Y, Fujita H, Mino K, Koyama T, Matsuoka S, Kaizuka T, Agawa M, Matsumoto S, Idei A, Nishikori M, Okuno Y, Osada H, Yoshida M, Takaori-Kondo A, Iwai K.: Synergistic involvement of the NZF domains of the LUBAC accessory subunits HOIL-1L and SHARPIN in the regulation of LUBAC function.
   Cell Death Dis, 15(11): 813 (2024) [ doi: 10.1038/s41419-024-07199-z ]
2. Lee DH, Lee HS, Choi MS, Parys K, Honda K, Kondoh Y, Lee JM, Edelbacher N, Heo G, Enugutti B, Osada H, Shirasu K, Belkhadir Y.: Reprogramming of flagellin receptor responses with surrogate ligands.
   Nat Commun, 15(1): 9811 (2024) [ doi: 10.1038/s41467-024-54271-5 ]
3. Usuki Y, Abe R, Nishiguchi K, Satoh T, Aono H, Nogawa T, Futamura Y, Osada H, Yoshida I, Fujita K, Mishima T, Fujita KI.: Total synthesis, stereochemical assignment, and biological evaluation of opantimycin A and analogues thereof.
   Org Biomol Chem, 22(45): 8973-8979 (2024) [ doi: 10.1039/d4ob01475h ]
4. Bradley JM, Bunsick M, Ly G, Aquino B, Wang FZ, Holbrook-Smith D, Suginoo S, Bradizza D, Kato N, As'sadiq O, Marsh N, Osada H, Boyer FD, McErlean CSP, Tsuchiya Y, Subramaniam R, Bonetta D, McCourt P, Lumba S.: Modulation of fungal phosphate homeostasis by the plant hormone strigolactone.
   Mol Cell, 84(20): 4031-4047.e11 (2024) [ doi: 10.1016/j.molcel.2024.09.004 ]
5. Sugiura R, Arazoe T, Motoyama T, Osada H, Kamakura T, Kuramochi K, Furuyama Y.: Pyricularia oryzae enhances Streptomyces griseus growth via non-volatile alkaline metabolites.
   Environ Microbiol Rep, 16(5): e70012 (2024) [ doi: 10.1111/1758-2229.70012 ]
6. Vu QV, Vu NT, Baba K, Sasaki S, Tamura R, Morimoto K, Hirano H, Osada H, Kataoka T.: Porphyrin derivatives inhibit tumor necrosis factor α-induced gene expression and reduce the expression and increase the cross-linked forms of cellular components of the nuclear factor κB signaling pathway.
   Eur J Pharmacol, 977([object Object]): 176747 (2024) [ doi: 10.1016/j.ejphar.2024.176747 ]
7. Nakahara M, Watanabe S, Sato M, Okumura H, Kawatani M, Osada H, Hara K, Hashimoto H, Watanabe K.: Structural and functional analyses of inhibition of human dihydroorotate dehydrogenase by antiviral furocoumavirin.
   Biochemistry, 63(10): 1241-1245 (2024) [ doi: 10.1021/acs.biochem.4c00120 ]
8. Davie T, Serrat X, Imhof L, Snider J, Štagljar I, Keiser J, Hirano H, Watanabe N, Osada H, Fraser AG.: Identification of a family of species-selective complex I inhibitors as potential anthelmintics.
   Nat Commun, 15(1): 3367 (2024) [ doi: 10.1038/s41467-024-47331-3 ]
9. A Abdelhakim I, Futamura Y, Asami Y, Hanaki H, Kito N, Masuda S, Shibata A, Muranaka A, Koshino H, Shirasu K, Osada H, Ishikawa J, Takahashi S.: Expression of Syo_1.56 SARP regulator unveils potent elasnin derivatives with antibacterial activity.
   J Nat Prod, 87(5): 1459-1470 (2024) [ doi: 10.1021/acs.jnatprod.4c00259 ]
10. Komaki H, Takagi H, Takahashi S, Osada H.: Reclassification of a reveromycin-producer and the proposals of Actinacidiphila reveromycinica sp. nov. and Actinacidiphila acidipaludis comb. nov.
    Biosci Biotechnol Biochem, 88(6):689-695 (2024) [ doi: 10.1093/bbb/zbae032 ]
11. Sakai K, Futamura Y, Nogawa T, Zhao Y, Koshino H, Osada H, Takahashi S.: Production of kinanthraquinone D with antimalarial activity by heterologous gene expression and biotransformation in Streptomyces lividans TK23.
    J Nat Prod, 87(4): 855-860 (2024) [ doi: 10.1021/acs.jnatprod.3c01076 ]
12. Yokota Y, Takaki K, Baba K, Sasaki S, Hirano H, Osada H, Kataoka T.: Amiodarone inhibits the Toll-like receptor 3-mediated nuclear factor κB signaling pathway by blocking organelle acidification.
    Biochem Biophys Res Commun, 708: 149801 (2024) [ doi: 10.1016/j.bbrc.2024.149801 ]
13. Vu QV, Baba K, Sasaki S, Kawaguchi K, Hirano H, Osada H, Kataoka T.: Alantolactone derivatives inhibit the tumor necrosis factor α-induced nuclear factor κB pathway by a different mechanism from alantolactone.
    Eur J Pharmacol, 969: 176458 (2024) [ doi: 10.1016/j.ejphar.2024.176458 ]

2023

1. Kawatani M, Aono H, Hiranuma S, Shimizu T, Muroi M, Nogawa T, Ohishi T, Ohba SI, Kawada M, Yamazaki K, Dan S, Dohmae N, Osada H.: Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling.
   Oncol Res, 31(6): 833-844 (2023) [ doi: 10.32604/or.2023.030241 ]
2. Kato N, Ebihara K, Nogawa T, Futamura Y, Inaba K, Okano A, Aono H, Fujikawa Y, Inoue H, Matsuda K, Osada H, Niwa R, Takahashi S.: cis-Decalin-containing tetramic acids as inhibitors of insect steroidogenic glutathione S-transferase Noppera-bo.
   PLoS One, 18(8): e0290851 (2023) [ doi: 10.1371/journal.pone.0290851 ]
3. Taniguchi S, Ono Y, Doi Y, Taniguchi S, Matsuura Y, Iwasaki A, Hirata N, Fukuda R, Inoue K, Yamaguchi M, Tashiro A, Egami D, Aoki S, Kondoh Y, Honda K, Osada H, Kumeta H, Saio T, Okiyoneda T.: Identification of α-Tocopherol succinate as an RFFL-substrate interaction inhibitor inducing peripheral CFTR stabilization and apoptosis.
   Biochem Pharmacol, 215: 115730 (2023) [ doi: 10.1016/j.bcp.2023.115730 ]
4. Liu Z, Ishikawa K, Sanada E, Semba K, Li J, Li X, Osada H, Watanabe N.: Identification of antimycin A as a c-Myc degradation accelerator via high-throughput screening.
   J Biol Chem, 299(9): 105083 (2023) [ doi: 10.1016/j.jbc.2023.105083 ]
5. Tan FHP, Ting ACJ, Najimudin N, Watanabe N, Shamsuddin S, Zainuddin A, Osada H, Azzam G.: 3-[[(3S)-1,2,3,4-Tetrahydroisoquinoline-3-carbonyl]amino]propanoic acid (THICAPA) is protective against Aβ42-induced toxicity in vitro and in an Alzheimer's Disease Drosophila.
   J Gerontol A Biol Sci Med Sci, 78(11): 1944-1952 (2023) [ doi: 10.1093/gerona/glad169 ]
6. Liu X, Sanada E, Li J, Li X, Osada H, Watanabe N.: Isolation and characterization of β-transducin repeat-containing protein ligands screened using a high-throughput screening system.
   Oncol Res, 31(5): 645-654 (2023) [ doi: 10.32604/or.2023.030240 ]
7. Liu Z, Okano A, Sanada E, Futamura Y, Nogawa T, Ishikawa K, Semba K, Li J, Li X, Osada H, Watanabe N.: Identification of microbial metabolites that accelerate the ubiquitin-dependent degradation of c-Myc.
   Oncol Res, 31(5): 655-666 (2023) [ doi: 10.32604/or.2023.030248 ]
8. Usukhbayar N, Takano Y, Uesugi S, Muroi M, Osada H, Kimura KI.: 3,6-Epidioxy-1,10-bisaboladiene induces ferroptosis-like cell death through lipid peroxidation.
   Free Radic Res, 57(3): 208-222 (2023) [ doi: 10.1080/10715762.2023.2229005 ]
9. Iyer KR, Li SC, Revie NM, Lou JW, Duncan D, Fallah S, Sanchez H, Skulska I, Ušaj MM, Safizadeh H, Larsen B, Wong C, Aman A, Kiyota T, Yoshimura M, Kimura H, Hirano H, Yoshida M, Osada H, Gingras AC, Andes DR, Shapiro RS, Robbins N, Mazhab-Jafari MT, Whitesell L, Yashiroda Y, Boone C, Cowen LE.: Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity.
   Cell Chem Biol, 30(7): 795-810.e8 (2023) [ doi: 10.1016/j.chembiol.2023.06.005 ]
10. Takayama KI, Matsuoka S, Adachi S, Honma T, Yoshida M, Doi T, Shin-Ya K, Yoshida M, Osada H, Inoue S.: Identification of small-molecule inhibitors against the interaction of RNA-binding protein PSF and its target RNA for cancer treatment.
    PNAS Nexus, 2(6): pgad203 (2023) [ doi: 10.1093/pnasnexus/pgad203 ]
11. Nogawa T, Kato N, Shimizu T, Okano A, Futamura Y, Takahashi S, Koshino H, Osada H.: Wakodecaline C, new tetrahydrofuran-fused decalin metabolite isolated from fungus Pyrenochaetopsis sp. RK10-F058.
    J Antibiot, 76(6): 346-350 (2023) [ doi: 10.1038/s41429-023-00613-2 ]
12. Okuda C, Ueda Y, Muroi M, Sanada E, Osada H, Shiono Y, Kimura KI, Takeda K, Kawaguchi K, Kataoka T.: Allantopyrone A interferes with the degradation of hypoxia-inducible factor 1α protein by reducing proteasome activity in human fibrosarcoma HT-1080 cells.
    J Antibiot, 76(6): 324-334 (2023) [ doi: 10.1038/s41429-023-00610-5 ]
13. Wang J, Fasina OB, Manzoor M, Wang Y, Liu Q, Mo J, Ohno H, Osada H, Xiang L, Qi J.: A new gentiopicroside derivative improves cognitive deficits of AD mice via activation of Wnt signaling pathway and regulation of gut microbiota homeostasis.
    Phytomedicine, 113: 154730 (2023) [ doi: 10.1016/j.phymed.2023.154730 ]
14. Sekine S, Takase S, Hayase R, Noritsugu K, Maemoto Y, Ichikawa Y, Ogawa K, Kondoh Y, Osada H, Yoshida M, Ito A.: Identification of a derivative of the alkaloid emetine as an inhibitor of the YAP-TEAD interaction and its potential as an anticancer agent.
    Biosci Biotechnol Biochem, 87(5): 501-510 (2023) [ doi: 10.1093/bbb/zbad022 ]
15. Motoyama T, Nogawa T, Shimizu T, Kawatani M, Kashiwa T, Yun CS, Hashizume D, Osada H.: Fungal NRPS-PKS hybrid enzymes biosynthesize new γ-lactam compounds, taslactams A-D, analogous to actinomycete proteasome inhibitors.
    ACS Chem Biol, 18(2): 396-403 (2023) [ doi: 10.1021/acschembio.2c00830 ]
16. Sato H, Fukui JN, Hirano H, Osada H, Arimura Y, Masuda M, Aida Y.: Application of the luminescence syncytium induction assay to identify chemical compounds that inhibit bovine leukemia virus replication.
    Viruses, 15(1): 4 (2023) [ doi: 10.3390/v15010004 ]

2022

1. Aoyama M, Ishikawa K, Nemoto S, Hirano H, Watanabe N, Osada H, Watanabe S, Semba K.: Lonidamine and domperidone inhibit expansion of transformed cell areas by modulating motility of surrounding nontransformed cells.
   J Biol Chem, 298(12): 102635 (2022) [ doi: 10.1016/j.jbc.2022.102635 ]
2. Manzoor M, Muroi M, Ogawa N, Kobayashi H, Nishimura H, Chen D, Fasina OB, Wang J, Osada H, Yoshida M, Xiang L, Qi J.: Isoquercitrin from Apocynum venetum L. produces an anti-obesity effect on obese mice by targeting C-1-tetrahydrofolate synthase, carbonyl reductase, and glutathione S-transferase P and modification of the AMPK/SREBP-1c/FAS/CD36 signaling pathway in mice in vivo.
   Food Funct, 13(21): 10923-10936 (2022) [ doi: 10.1039/d2fo02438a ]
3. Forster DT, Li SC, Yashiroda Y, Yoshimura M, Li Z, Isuhuaylas LAV, Itto-Nakama K, Yamanaka D, Ohya Y, Osada H, Wang B, Bader GD, Boone C.: BIONIC: biological network integration using convolutions.
   Nat Methods, 19(10): 1250-1261 (2022) [ doi: 10.1038/s41592-022-01616-x ]
4. Burger M, Honda K, Kondoh Y, Hong S, Watanabe N, Osada H, Chory J.: Crystal structure of Arabidopsis DWARF14-LIKE2 (DLK2) reveals a distinct substrate binding pocket architecture.
   Plant Direct, 6(9): e446 (2022) [ doi: 10.1002/pld3.446 ]
5. Shiraishi Y, Maehama T, Nishio M, Otani J, Hikasa H, Mak TW, Sasaki T, Honma T, Kondoh Y, Osada H, Yoshida M, Fujisawa M, Suzuki A.: N-(3,4-dimethoxyphenethyl)-6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-amine inhibits bladder cancer progression by suppressing YAP1/TAZ.
   Genes Cells, 27(10): 602-612 (2022) [ doi: 10.1111/gtc.12979 ]
6. Dhital RN, Sen A, Hu H, Ishii R, Sato T, Yashiroda Y, Kimura H, Boone C, Yoshida M, Futamura Y, Hirano H, Osada H, Hashizume D, Uozumi Y, Yamada YMA.: Phenylboronic ester-activated aryl iodide-selective buchwald-hartwig-type amination toward bioactivity assay.
   ACS Omega, 7(28): 24184-24189 (2022) [ doi: 10.1021/acsomega.2c01092 ]
7. Revie NM, Iyer KR, Maxson ME, Zhang J, Yan S, Fernandes CM, Meyer KJ, Chen X, Skulska I, Fogal M, Sanchez H, Hossain S, Li S, Yashiroda Y, Hirano H, Yoshida M, Osada H, Boone C, Shapiro RS, Andes DR, Wright GD, Nodwell JR, Del Poeta M, Burke MD, Whitesell L, Robbins N, Cowen LE.: Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation.
   Nat Commun, 13(1): 3634 (2022) [ doi: 10.1038/s41467-022-31308-1 ]
8. Fasina OB, Wang J, Mo J, Osada H, Ohno H, Pan W, Xiang L, Qi J.: Gastrodin from Gastrodia elata enhances cognitive function and neuroprotection of AD mice via the regulation of gut microbiota composition and inhibition of neuron inflammation.
   Front Pharmacol, 13: 814271 (2022) [ doi: 10.3389/fphar.2022.814271 ]
9. Ono A, Suzuki T, Takeshima Y, Kashiwa T, Motoyama T, Choi JH, Sato C, Konno N, Miyakawa H, Ogata M, Hirai H, Dohra H, Osada H, Kawagishi H.: CmLec4, a lectin from the fungus cordyceps militaris, controls host infection and fruiting body formation.
   Int J Biol Macromol, 215: 303-311 (2022) [ doi: 10.1016/j.ijbiomac.2022.06.106 ]
10. Cho N, Kikuzato K, Futamura Y, Shimizu T, Hayase H, Kamisaka K, Takaya D, Yuki H, Honma T, Niikura M, Kobayashi F, Watanabe N, Osada H, Koyama H.: New antimalarials identified by a cell-based phenotypic approach: Structure-activity relationships of 2,3,4,9-tetrahydro-1H-β-carboline derivatives possessing a 2-((coumarin-5-yl)oxy)alkanoyl moiety.
    Bioorg Med Chem, 66: 116830 (2022) [ doi: 10.1016/j.bmc.2022.116830 ]
11. Abdelhakim IA, Motoyama T, Nogawa T, Mahmud FB, Futamura Y, Takahashi S, Osada H.: Isolation of new lucilactaene derivatives from P450 monooxygenase and aldehyde dehydrogenase knockout Fusarium sp. RK97-94 strains and their biological activities.
    J Antibiot, 75(7): 361-374 (2022) [ doi: 10.1038/s41429-022-00529-3 ]
12. Nakaya T, Aizawa K, Taguchi Y, Tsuji K, Sekine S, Murakami K, Kasai M, Nakano H, Kondoh Y, Dan S, Yoshimori A, Kouji H, Takehara D, Suzuki T, Osada H, Murata M, Tanaka A, Nagai R.: Development of low-molecular-weight compounds targeting the cancer-associated KLF5 transcription factor.
    ACS Med Chem Lett, 13(4): 687-694 (2022) [ doi: 10.1021/acsmedchemlett.1c00721 ]
13. Motoyama T, Kondoh Y, Shimizu T, Hayashi T, Honda K, Uchida M, Osada H.: Identification of scytalone dehydratase inhibitors effective against melanin biosynthesis dehydratase inhibitor-resistant Pyricularia oryzae.
    J Agric Food Chem, 70(10): 3109-3116 (2022) [ doi: 10.1021/acs.jafc.1c04984 ]
14. Mendoza A, Takemoto Y, Cruzado KT, Masoud SS, Nagata A, Tantipanjaporn A, Okuda S, Kawagoe F, Sakamoto R, Odagi M, Mototani S, Togashi M, Kawatani M, Aono H, Osada H, Nakagawa H, Higashi T, Kittaka A, Nagasawa K, Uesugi M.: Controlled lipid β-oxidation and carnitine biosynthesis by a vitamin D metabolite.
    Cell Chem Biol, 29(4): 660-669.e12 (2022) [ doi: 10.1016/j.chembiol.2021.08.008 ]
15. Takemori T, Sugimoto-Ishige A, Nishitsuji H, Futamura Y, Harada M, Kimura-Someya T, Matsumoto T, Honma T, Tanaka M, Yaguchi M, Isono K, Koseki H, Osada H, Miki D, Saito T, Tanaka T, Fukami T, Goto T, Shirouzu M, Shimotohno K, Chayama K.: Establishment of a monoclonal antibody against human NTCP that blocks hepatitis B virus infection.
    J Virol, 96(5): e0168621 (2022) [ doi: 10.1128/JVI.01686-21 ]
16. A Abdelhakim I, Bin Mahmud F, Motoyama T, Futamura Y, Takahashi S, Osada H.: Dihydrolucilactaene, a potent antimalarial compound from Fusarium sp. RK97-94.
    J Nat Prod, 85(1): 63-69 (2022) [ doi: 10.1021/acs.jnatprod.1c00677 ]
17. Yoshioka H, Kawamura T, Muroi M, Kondoh Y, Honda K, Kawatani M, Aono H, Waldmann H, Watanabe N, Osada H.: Identification of a small molecule that enhances ferroptosis via inhibition of ferroptosis suppressor protein 1 (FSP1).
    ACS Chem Biol, 17(2): 483-491 (2022) [ doi: 10.1021/acschembio.2c00028 ]
18. Jang JP, Jang M, Nogawa T, Takahashi S, Osada H, Ahn JS, Ko SK, Jang JH.: RK-270D and E, Oxindole derivatives from Streptomyces sp. with anti-angiogenic activity.
    J Microbiol Biotechnol, 32(3): 302-306 (2022) [ doi: 10.4014/jmb.2110.10039 ]
19. Liu H, Panjikar S, Sheng X, Futamura Y, Zhang C, Shao N, Osada H, Zou H.: β-methyltryptamine provoking the crucial role of strictosidine synthase Tyr151-OH for its stereoselective pictet-spengler reactions to tryptoline-type alkaloids.
    ACS Chem Biol, 17(1): 187-197 (2022) [ doi: 10.1021/acschembio.1c00844 ]

-2021

　Research publications through FY2021 are available on the Chemical Biology Research Group's website.

　　　　Chemical Biology Research Groups Publication

Design by Megapx　 Template by s-hoshino.com