ケミカルバイオロジー研究グループ（終了）
Cytotrienin A, B
- Structure
-
A:
B:
- Producing organism
- Streptomyces sp. RK95-74
- Biological activity
- cytotoxic, apoptosis inducing activity
- Abstract
- Cytotrienin A and B, two novel triene-ansamycins containing a unique 1-aminocyclopropane carboxylic acid moiety, were isolated from the culture broth of Streptomyces sp. through a separation procedure guided by the cytotoxic activity in vitro. The structures were elucidated on the basis of spectroscopic data. Cytotrienins A nad B exhibited a potent apoptosis-nducing actibity on human leukemia HL-60 cells.
- References
-
isolation and structural determination
- Zhang HP, Kakeya H, Osada H.
Novel triene-ansamycins, cytotrienins A and B, inducing apoptosis on human leukemia HL-60 cells.
Tetrahedron Letter 38, 1789-1792 (1997) [ doi: 10.1016/S0040-4039(97)00170-6 ]- Kakeya H, Zhang HP, Kobinata K, Onose R, Onozawa C, Kudo T, Osada H.: Cytotrienin A, a novel apoptosis inducer in human leukemia HL-60 cells.
J Antibiot, 50(4): 370-372 (1997)
biosynthetic studies- Zhang HP, Kakeya H, Osada H.
Biosynthesis of 1-aminocyclopropane-1-carboxylic acid moiety on cytotrienin A in Streptomyces sp.
Tetrahedron Letter 39, 6947-6948 (1998) [ doi: 10.1016/S0040-4039(98)01460-9 ]biological activities- Kakeya H, Onose R, Osada H.: Caspase-mediated activation of a 36-kDa myelin basic protein kinase during anticancer drug-induced apoptosis.
Cancer Res, 58(21): 4888-4894 (1998)- Watabe M, Kakeya H, Onose R, Osada H.: Activation of MST/Krs and c-Jun N-terminal kinases by different signaling pathways during cytotrienin A-induced apoptosis.
J Biol Chem, 275(12): 8766-8771 (2000) - Zhang HP, Kakeya H, Osada H.