プレスリリース

遺伝子資源を化合物資源へ－生合成遺伝子の異種発現による安定生産で実現－

2020-12-15

Nogawa T, Terai A, Amagai K, Hashimoto J, Futamura Y, Okano A, Fujie M, Satoh N, Ikeda H, Shin-Ya K, Osada H, Takahashi S.: Heterologous expression of the biosynthetic gene cluster for verticilactam and identification of analogues.
J Nat Prod, [Epub ahead of print] (2020) [ doi: 10.1021/acs.jnatprod.0c00755 ]
機能低下したミトコンドリアを活性化させる化合物－解糖系酵素ホスホフルクトキナーゼ阻害剤とその新活性の発見－

2020-11-10

Kobayashi H, Hatakeyama H, Nishimura H, Yokota M, Suzuki S, Tomabechi Y, Shirouzu M, Osada H, Mimaki M, Goto YI, Yoshida M.: Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations.
Nat Chem Biol, [Epub ahead of print] (2020) [ doi: 10.1038/s41589-020-00676-4 ]
かび毒を作るメカニズム－テヌアゾン酸生合成酵素の立体構造解明に成功－

2020-10-27

Yun CS, Nishimoto K, Motoyama T, Shimizu T, Hino T, Dohmae N, Nagano S, Osada H.: Unique features of the ketosynthase domain in a non-ribosomal peptide synthetase-polyketide synthase hybrid enzyme, tenuazonic acid synthetase 1.
J Biol Chem, 295(33): 11602-11612 (2020) [ doi: 10.1074/jbc.RA120.013105 ]
天然化合物の生産を増強する小分子－二次代謝物生産を増強するβカルボリン作用機構の解明－

2020-09-11

Panthee S, Kito N, Hayashi T, Shimizu T, Ishikawa J, Hamamoto H, Osada H, Takahashi S.: β-carboline chemical signals induce reveromycin production through a LuxR family regulator in Streptomyces sp. SN-593.
Sci Rep, 10(1): 10230 (2020) [ doi: 10.1038/s41598-020-66974-y ]
農薬が害虫だけでなく有機汚染物質からも作物を守る ― ウリ科作物で実証 ―

2020-07-18

Fujita K, Kondoh Y, Honda K, Haga Y, Osada H, Matsumura C, Inui H.: Pesticide treatment reduces hydrophobic pollutant contamination in Cucurbita pepo through competitive binding to major latex-like proteins.
Environ Pollut, (2020) in press [ doi: 10.1016/j.envpol.2020.115179 ]
植物の耐塩性を強化する化合物を新たに発見－農作物を塩害に強くする肥料や農薬の開発に貢献－

2020-05-26

Sako K, Futamura Y, Shimizu T, Matsui A, Hirano H, Kondoh Y, Muroi M, Aono H, Tanaka M, Honda K, Shimizu K, Kawatani M, Nakano T, Osada H, Noguchi K, Seki M.: Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana.
Sci Rep, 10(1): 8691 (2020) [ doi: 10.1038/s41598-020-65614-9 ]
化合物と結合する標的タンパク質の網羅的解析法を構築

2019-12-05

Nagasawa I, Muroi M, Kawatani M, Ohishi T, Ohba S, Kawada K, Osada H.: Identification of a small compound targeting PKM2-regulated signaling using 2D gel electrophoresis-based proteome-wide CETSA.
Cell Chem Biol, (2019) in press [ doi: 10.1016/j.chembiol.2019.11.010 ]
キノコの新しい生理活性物質－創薬研究に貢献するユニークな化学構造－

2018-10-19

Otaka J, Shimizu T, Futamura Y, Hashizume D, Osada H.: Structures and Synthesis of Hitoyopodins: Bioactive Aromatic Sesquiterpenoids Produced by the Mushroom Coprinopsis cinerea.
Org Lett, 20(19): 6294-6297 (2018) [ doi: 10.1021/acs.orglett.8b02788 ]
鏡像異性体を作り分ける酵素の発見－酵素による[4+2]環化付加反応における立体選択性の制御－

2018-07-05

Kato N, Nogawa T, Takita R, Kinugasa K, Kanai M, Uchiyama M, Osada H, Takahashi S.: Control of the Stereochemical Course of [4+2] Cycloaddition during trans-Decalin Formation by Fsa2-Family Enzymes.
Angew Chem Int Ed Engl, [Epub ahead of print] (2018) [ doi: 10.1002/anie.201805050 ]
オカラミンの化学構造と殺虫活性の関係－生合成研究により解明された殺虫活性に必須な部分構造－

2018-05-25

Kato N, Furutani S, Otaka J, Noguchi A, Kinugasa K, Kai K, Hayashi H, Ihara M, Takahashi S, Matsuda K, Osada H.: Biosynthesis and structure-activity relationship studies of okaramines that target insect glutamate-gated chloride channels.
ACS Chem Biol, 13(3): 561-566 (2018) [ doi: 10.1021/acschembio.7b00878 ]
植物病原菌や毒素生産菌の無性生殖を引き起こす内因性の新物質を発見

2018-05-17

Qi J, Cheng L, Sun Y, Hirata Y, Ushida N, Ma Z, Osada H, Nishikawa T, Xiang L.: Identification of an Asexual Reproduction Inducer of Phytopathogenic and Toxigenic Fusarium.
Angew Chem Int Ed Engl, 57(27): 8100-8104 (2018) [ doi: 10.1002/anie.201803329]
放線菌を用いたボツリオコッセン生産－テルペノイド生産プラットフォームの開発－

2017-12-12

Khalid A, Takagi H, Panthee S, Muroi M, Chappell J, Osada H & Takahashi S.: Development of a Terpenoid-Production Platform in Streptomyces reveromyceticus SN-593.
ACS Synthetic Biology, (2017) [ doi: 10.1021/acssynbio.7b00249 ]
血糖値をさげる新しい化合物を同定－カイコを用いた新規薬物の同定と解析－

2017-09-15

Enomoto R, Kurosawa A, Nikaido Y, Mashiko M, Saheki T, Nakajima N, Kuroiwa S, Otobe M, Ohsaki M, Tooyama K, Inoue Y, Kuwabara N, Kikuchi O, Kitamura T, Kojima I, Nakagawa Y, Saito T, Osada H, Futahashi M, Sezutsu H, Takeda S.: A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test.
Eur J Pharmacol, 814([object Object]): 130-137 (2017) [ doi: 10.1016/j.ejphar.2017.08.017 ]
かび毒の生産制御機構－テヌアゾン酸の生産制御因子を同定－

2017-10-06

Yun CS, Motoyama T, Osada H.: Regulatory Mechanism of Mycotoxin Tenuazonic Acid Production in Pyricularia oryzae.
ACS Chem Biol, 12(9): 2270-2274 (2017) [ doi: 10.1021/acschembio.7b00353 ]
化合物の標的機能を決定するツールを開発－酵母の化学遺伝学アプローチで化合物の標的予測／同定が迅速に－

2017-07-25

Piotrowski JS, Li SC, Deshpande R, Simpkins SW, Nelson J, Yashiroda Y, Barber JM, Safizadeh H, Wilson E, Okada H, Gebre AA, Kubo K, Torres NP, LeBlanc MA, Andrusiak K, Okamoto R, Yoshimura M, DeRango-Adem E, van Leeuwen J, Shirahige K, Baryshnikova A, Brown GW, Hirano H, Costanzo M, Andrews B, Ohya Y, Osada H, Yoshida M, Myers CL, Boone C.: Functional annotation of chemical libraries across diverse biological processes.
Nat Chem Biol, 13(9): 982-993 (2017) [ doi: 10.1038/nchembio.2436 ]
植物細胞の伸長を促進する新しいタンパク質を発見－植物の葉のサイズ・草丈を制御する技術開発に貢献－

2017-07-18

Yamagami A, Saito C, Nakazawa M, Fujioka S, Uemura T, Matsui M, Sakuta M, Shinozaki K, Osada H, Nakano A, Asami T, Nakano T.: Evolutionarily conserved BIL4 suppresses the degradation of brassinosteroid receptor BRI1 and regulates cell elongation.
Sci Rep, 7(1): 5739 (2017) [ doi: 10.1038/s41598-017-06016-2 ]
新しいカルボキシル化酵素の発見－天然有機化合物の構造多様性を創出する新規生合成経路の解明－

2017-01-17

Ray L, Valentic TR, Miyazawa T, Withall DM, Song L, Milligan JC, Osada H, Takahashi S, Tsai SC, Challis GL.: A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units.
Nat Commun, 7: 13609 (2016) [ doi: 10.1038/ncomms13609 ]
ポリケチド化合物の骨格形成に重要な酵素の機能解明－生理活性を持つ天然化合物の構造多様化に繋がる第一歩－

2015-11-12

Miyazawa T, Takahashi S, Kawata A, Panthee S, Hayashi T, Shimizu T, Nogawa T, Osada H.: Identification of Middle Chain Fatty Acyl-CoA Ligase Responsible for the Biosynthesis of 2-Alkylmalonyl-CoAs for Polyketide Extender Unit.
J Biol Chem, 290(45): 26994-27011 (2015) [ doi: 10.1074/jbc.M115.677195 ]
酵母のアミノ酸取り込みを調節する化合物を発見－分裂酵母細胞間のコミュニケーションを担う新規オキシリピン「NSF」－

2016-02-26

Sun X, Hirai G, Ueki M, Hirota H, Wang Q, Hongo Y, Nakamura T, Hitora Y, Takahashi H, Sodeoka M, Osada H, Hamamoto M, Yoshida M, Yashiroda Y.: Identification of novel secreted fatty acids that regulate nitrogen catabolite repression in fission yeast.
Sci Rep, 6: 20856 (2016) [ doi: 10.1038/srep20856 ]
植物の青色光特異的伸長化合物を同定－クリプトクロムの青色光による光情報の阻害化合物の発見－

2016-12-14

Ong WD, Okubo-Kurihara E, Kurihara Y, Shimada S, Makita Y, Kawashima M, Honda K, Kondoh Y, Watanabe N, Osada H, Cutler SR, Sudesh K, Matsui M.: Chemical-Induced Inhibition of Blue Light-Mediated Seedling Development Caused by Disruption of Upstream Signal Transduction Involving Cryptochromes in Arabidopsis thaliana.
Plant Cell Physiol, 58 (1): 95-105 (2017) [ doi: 10.1093/pcp/pcw181 ]
インスリン分泌を阻害しているタンパク質の機能を発見

2016-10-03

Kunii M, Ohara-Imaizumi M, Takahashi N, Kobayashi M, Kawakami R, Kondoh Y, Shimizu T, Simizu S, Lin B, Nunomura K, Aoyagi K, Ohno M, Ohmuraya M, Sato T, Yoshimura SI, Sato K, Harada R, Kim YJ, Osada H, Nemoto T, Kasai H, Kitamura T, Nagamatsu S, Harada A.: Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells.
J Cell Biol, 215(1): 121-138 (2016) [ doi: 10.1083/jcb.201604030 ]
放線菌におけるアミノ基キャリアタンパク質を介した二次代謝経路の発見

2016-09-27

Hasebe F, Matsuda K, Shiraishi T, Futamura Y, Nakano T, Tomita T, Ishigami K, Taka H, Mineki R, Fujimura T, Osada H, Kuzuyama T, Nishiyama T
Amino group carrier protein-mediated secondary metabolite biosynthesis in Streptomyces
Nat Chem Biol , 12: 967–972 (2016) [ doi: 10.1038/nchembio.2181 ]
アブシジン酸と拮抗的に働く新規化合物を同定－約2万4,000の化合物を固定化したアレイで探索－

2015-10-30

Ito T, Kondoh Y, Yoshida K, Umezawa T, Shimizu T, Shinozaki K, Osada H.: Novel Abscisic Acid Antagonists Identified with Chemical Array Screening.
Chembiochem, 16(17): 2471-2478 (2015) [ doi: 10.1002/cbic.201500429 ]
新規セスキテルペン生合成遺伝子の発見－麹菌二次代謝産物のアステロライド生合成の解明－

2016-09-26

Shinohara Y, Takahashi S, Osada H, Koyama Y.: Identification of a novel sesquiterpene biosynthetic machinery involved in astellolide biosynthesis.
Sci Rep, 6: 32865 (2016) [ doi: 10.1038/srep32865 ]
エイズウイルスの細胞間感染の新たなメカニズムを解明－異なる作用メカニズムによる新規エイズ治療薬開発の可能性－

2016-01-18

Hashimoto M, Bhuyan F, Hiyoshi M, Noyori O, Nasser H, Miyazaki M, Saito T, Kondoh Y, Osada H, Kimura S, Hase K, Ohno H, Suzu S.: Potential Role of the Formation of Tunneling Nanotubes in HIV-1 Spread in Macrophages.
J Immunol, 196(4): 1832-1841 (2016) [ doi: 10.4049/jimmunol.1500845 ]
かび毒テヌアゾン酸の生合成遺伝子を同定 ―新しいタイプの二次代謝産物生合成酵素を発見―

2015-10-27

Yun CS, Motoyama T, Osada H.: Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme.
Nat Commun, 6: 8758 (2015) [ doi: 10.1038/ncomms9758 ]
微生物が特定の形の代謝物を作るために必要な酵素遺伝子を発見－複雑な立体構造の二次代謝物を作るメカニズムの全容解明への第一歩－

2015-04-28

Kato N, Nogawa T, Hirota H, Jang JH, Takahashi S, Ahn JS, Osada H.: A new enzyme involved in the control of the stereochemistry in the decalin formation during equisetin biosynthesis.
Biochem Biophys Res Commun, 460(2): 210-215 (2015) [ doi: 10.1016/j.bbrc.2015.03.011 ]
プロファイリングで、抗がん剤候補物質の作用機序を解明－独自のプロテオームプロファイリングシステムで薬剤標的を迅速同定－

2011-06-24

Kawatani M, Takayama H, Muroi M, Kimura S, Maekawa T, Osada H.: Identification of a small-molecule inhibitor of DNA topoisomerase II by proteomic profiling.
Chem Biol, 18(6): 743-751 (2011) [ doi: 10.1016/j.chembiol.2011.03.012 ]
タンパク質の「集合と拡散」による植物草丈制御の仕組みを発見

2015-02-07

Shimada S, Komatsu T, Yamagami A, Nakazawa M, Matsui M, Kawaide H, Natsume M, Osada H, Asami T, Nakano T.: Formation and dissociation of the BSS1 protein complex regulates plant development via brassinosteroid signaling.
Plant Cell, 27(2): 375-390 (2015) [ doi: 10.1105/tpc.114.131508 ]
抗がん剤の種「テルペンドールE」の生合成メカニズムを解明－テルペンドールEはかび毒生合成のカギとなる中間体だった－

2012-12-21

Motoyama T, Hayashi T, Hirota H, Ueki M, Osada H.: Terpendole E, a kinesin Eg5 inhibitor, is a key biosynthetic intermediate of indole-diterpenes in the producing fungus Chaunopycnis alba.
Chem Biol, 19(12): 1611-1619 (2012) [ doi: 10.1016/j.chembiol.2012.10.010 ]
がん細胞の「かたち」で簡単に抗がん剤の作用を予測－抗がん剤創薬に向けた新しいアプローチ－

2012-12-21

Futamura Y, Kawatani M, Kazami S, Tanaka K, Muroi M, Shimizu T, Tomita K, Watanabe N, Osada H.: Morphobase, an encyclopedic cell morphology database, and its use for drug target identification.
Chem Biol, 19(12): 1620-1630 (2012) [ doi: 10.1016/j.chembiol.2012.10.014 ]
薬剤の生体内標的分子を予測するプロテオミクスシステムを構築

2010-05-28

Muroi M, Kazami S, Noda K, Kondo H, Takayama H, Kawatani M, Usui T, Osada H.: Application of proteomic profiling based on 2D-DIGE for classification of compounds according to the mechanism of action.
Chem Biol, 17(5): 460-470 (2010) [ doi: 10.1016/j.chembiol.2010.03.016 ]
タンパク質機能の謎を解く新たなカギは小分子化合物－高速探索システム「化合物アレイ」で新規バイオプローブを発見－

2010-08-16

Miyazaki I, Simizu S, Okumura H, Takagi S, Osada H.: A small-molecule inhibitor shows that pirin regulates migration of melanoma cells.
Nat Chem Biol, 6(9): 667-673 (2010) [ doi: 10.1038/nchembio.423 ]
放線菌による「リベロマイシンA」生合成機序を遺伝子レベルで初めて解明－トマトエキスが誘導する放線菌遺伝子を探索し判明－

2011-06-06

Takahashi S, Toyoda A, Sekiyama Y, Takagi H, Nogawa T, Uramoto M, Suzuki R, Koshino H, Kumano T, Panthee S, Dairi T, Ishikawa J, Ikeda H, Sakaki Y, Osada H.: Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation.
Nat Chem Biol, 7(7): 461-468 (2011) [ doi: 10.1038/nchembio.583 ]

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プレスリリース