ケミカルバイオロジー研究グループ（終了）
Phoslactomycin A, B, C, D, E, F Phosphazomycin C1, C2
- Structure
-
Phoslactomycin
A:
B:
C:
D:
E:
F:
Phosphazomycin
C1:
C2:
- Producing organism
- Streptomyces sp.
- Biological activity
- protein phosphatase 2A inhibitor
- Abstract
- -----
- References
-
isolation and structural determination
- Uramoto M, Shen YC, Takizawa N, Kusakabe H, Isono K.: A new antifungal antibiotic, phosphazomycin A.
J Antibiot, 38(5): 665-668 (1985)
- Tomiya T, Uramoto M, Isono K.: Isolation and structure of phosphazomycin C.
J Antibiot, 43(1): 118-121 (1990)- Fushimi S, Nishikawa S, Shimazu A, Seto H.: Studies on new phosphate ester antifungal antibiotics phoslactomycins. I. Taxonomy, fermentation, purification and biological activities.
J Antibiot, 42(7): 1019-1025 (1989)- Fushimi S, Furihata K, Seto H.: Studies on new phosphate ester antifungal antibiotics phoslactomycins. II. Structure elucidation of phoslactomycins A to F.
J Antibiot, 42(7): 1026-1036 (1989)biological activity- Usui T, Marriott G, Inagaki M, Swarup G, Osada H.: Protein phosphatase 2A inhibitors, phoslactomycins. Effects on the cytoskeleton in NIH/3T3 cells.
J Biochem, 125(5): 960-965 (1999)biosynthesis study- Palaniappan N, Kim BS, Sekiyama Y, Osada H, Reynolds KA.: Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster.
J Biol Chem, 278(37): 35552-35557 (2003) [ doi: 10.1074/jbc.M305082200 ]- Sekiyama Y, Palaniappan N, Kim BS, Reynolds KA, Osada H
Biosynthesis of phoslactomycins: cyclohexanecarboxylic acid as the starter unit.
Tetrahedron,59, 7465-7471 (2003) [ doi: 10.1016/S0040-4020(03)01205-5 ] - Uramoto M, Shen YC, Takizawa N, Kusakabe H, Isono K.: A new antifungal antibiotic, phosphazomycin A.