ケミカルバイオロジー研究グループ（終了）
Respinomycin A1, A2, B, C, D
Structure
| Respinomycin | R1 | R2 | R3 | |
|---|---|---|---|---|
| A1 |  |
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 |
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| A2 | |
|
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| B | |
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| C | |
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| D |  |
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- Producing organism
- Streptomyces xanthocidicus (isolated in Nagano, Japan)
- Biological activity
- induction of cell differentiaion, antiphage activity
- Abstract
- Respinomycins are a novel group of anthracycline antibiotics produced by Streptomyces xanthocidicus. Respinomycins A1, A2, B, C and D were isolated by EtOAc extraction, silica gel column chromatography, centrifugal partition chromatography and preparative silica gel thin layer chromatography. Respinomycins A1 and A2 induced the terminal differentiation of human leukemia K-562 cells.
- References
-
isolation and structural determination
- Ubukata M, Tanaka C, Osada H, Isono K.: Respinomycin A1, a new anthracycline antibiotic.
J Antibiot, 44(11): 1274-1276 (1991)
- Ubukata M, Osada H, Kudo T, Isono K.: Respinomycins A1, A2 B, C and D, a novel group of anthracycline antibiotics. I. Taxonomy, fermentation, isolation and biological activities.
J Antibiot, 46(6): 936-941 (1993)- Ubukata M, Uzawa J, Osada H, Isono K.: Respinomycins A1, A2, B, C and D, a novel group of anthracycline antibiotics. II. Physico-chemical properties and structure elucidation.
J Antibiot, 46(6): 942-951 (1993) - Ubukata M, Tanaka C, Osada H, Isono K.: Respinomycin A1, a new anthracycline antibiotic.