ケミカルバイオロジー研究グループ（終了）
RS-22A - C
- Structure
-
A:
B:
C:
- Producing organism
- Streptomyces violaceusnigar
- Biological activity
- antimicrobial activity
- Abstract
- Three novel 36-membered macrolide antibiotics, RS-22A, B and C produced by Streptomyces violaceusniger have been isolated. These antibiotics were purified from an acetone extract of the mycelia followed by butanol extraction, centrifugal partition chromatography and HPLC. RS-22A, B, C showed antimicrobial activity against fungi and Gram-positive bacteria.
- References
-
isolation and structural determination
- Ubukata M, Shiraishi N, Kobinata K, Kudo T, Yamaguchi I, Osada H, Shen YC, Isono K.: RS-22A, B and C: new macrolide antibiotics from Streptomyces violaceusniger. I. Taxonomy, fermentation, isolation and biological activities.
J Antibiot, 48(4): 289-292 (1995)
- Ubukata M, Morita T, Osada H.: RS-22A, B and C: new macrolide antibiotics from Streptomyces violaceusniger. II. Physico-chemical properties and structure elucidation.
J Antibiot, 48(4): 293-299 (1995) - Ubukata M, Shiraishi N, Kobinata K, Kudo T, Yamaguchi I, Osada H, Shen YC, Isono K.: RS-22A, B and C: new macrolide antibiotics from Streptomyces violaceusniger. I. Taxonomy, fermentation, isolation and biological activities.